You know, there really have been frogs in space.
In 1961 the russians sent a frog into (shallow) space.
And not to be outdone, in 1967 the Yanks sent frogs eggs into space.
In 1970 two bullfrogs went on a one-way mission on the Orbiting Frog Otolith satellite to better understand space motion sickness. How did they report back?
It took until the 1980s before the first newts made it to space (crazy Russians again). And after that they became quite popular.
(Man in space examining newt. True.)
I'd like to thank Wikipedia for this little educational post. Follow the link if you want more info - but vegetarians and animal lovers be warned. Lots of these trips were strictly one way.